Renin–angiotensin–aldosterone system (RAAS) plays important roles in regulating renal
hemodynamics and functions, as well as in the pathophysiology of hypertension and renal …

In vitro studies suggest that collecting duct–derived (CD-derived) endothelin-1 (ET-1) can
regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is …

Angiotensin II (AngII) infusions augment renal angiotensinogen mRNA and protein and
urinary angiotensinogen excretion (UAGT). Further experiments were performed in 4 groups …

Sodium reabsorption and potassium secretion in the distal convoluted tubule and in the
connecting tubule can maintain the homeostasis of the body, especially when dietary …

We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index
of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent …

Distal nephron renin may provide a possible pathway for angiotensin (Ang) I generation
from proximally delivered angiotensinogen. To examine the effects of Ang II on distal …

Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease (ESKD)
worldwide. Mineralocorticoid receptor (MR) plays an important role in the development of …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

The existence of a local renin angiotensin system (RAS) of the kidney has been established.
Angiotensinogen (AGT), renin, angiotensin-converting enzyme (ACE), angiotensin …

Angiotensin (Ang) II-infused hypertensive rats exhibit increases in renal angiotensinogen
mRNA and protein, as well as urinary angiotensinogen excretion in association with …