Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?

E Rodríguez-Correa, I González-Pérez… - Nutrition & …, 2020 - nature.com
Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance,
dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and …

Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking

N Linscheid, SJRJ Logantha, PC Poulsen… - Nature …, 2019 - nature.com
The sinus node is a collection of highly specialised cells constituting the heart's pacemaker.
The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution …

[HTML][HTML] CrossTalk opposing view: bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node

A D'Souza, S Sharma, MR Boyett - The Journal of physiology, 2015 - ncbi.nlm.nih.gov
It is well known that athletes have a low resting heart rate (bradycardia). The bradycardia
can be moderate to severe: reports of heart rates of 40–60 beats min− 1 in athletes are …

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice

E Soltysinska, T Speerschneider, SV Winther… - Cardiovascular …, 2014 - Springer
Background The aim of this study was to probe cardiac complications, including heart-rate
control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is …

Heart rate variability as early biomarker for the evaluation of diabetes mellitus progress

RE Arroyo-Carmona, AL López-Serrano… - Journal of diabetes …, 2016 - Wiley Online Library
According to the American Diabetes Association (ADA), the side effects of diabetes mellitus
have recently increased the global health expenditure each year. Of these, the early …

[HTML][HTML] Tale of two kinases: Protein kinase A and Ca2+/calmodulin-dependent protein kinase II in pre-diabetic cardiomyopathy

P Gaitán-González, R Sánchez-Hernández… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Metabolic syndrome is a pre-diabetic state characterized by several biochemical and
physiological alterations, including insulin resistance, visceral fat accumulation, and …

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation

GE Kim, JL Ross, C Xie, KN Su, VG Zaha… - Cardiovascular …, 2015 - academic.oup.com
Abstract Aims Liver kinase B1 (LKB1) is a protein kinase that activates the metabolic
regulator AMP-activated protein kinase (AMPK) and other related kinases. Deletion of LKB1 …

The effects of sucrose and arsenic on muscular insulin signaling pathways differ between the gastrocnemius and quadriceps muscles

P Pánico, M Velasco, AM Salazar… - Frontiers in …, 2023 - frontiersin.org
Introduction Insulin resistance in muscle can originate from a sedentary lifestyle,
hypercaloric diets, or exposure to endocrine-disrupting pollutants such as arsenic. In …

A maternal diet high in carbohydrates causes bradyarrhythmias and changes in heart rate variability in the offspring sex-dependent in mice

RE Arroyo-Carmona, Y Mitre-Velasco… - Laboratory Animal …, 2024 - Springer
Background Maternal obesity prepregnancy, as well as gestational overweight produced by
high-sucrose diet, could be evolved to the cardiometabolic diseases in offspring during …

The role of the autonomic nervous system on cardiac rhythm during the evolution of diabetes mellitus using heart rate variability as a biomarker

A Albarado-Ibañez, RE Arroyo-Carmona… - Journal of diabetes …, 2019 - Wiley Online Library
Heart rate variability (HRV) is highly influenced by the Autonomic Nervous System (ANS).
Several illnesses have been associated with changes in the ANS, thus altering the pattern of …