Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

P450BM3 (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been
extensively studied over a period of almost forty years. The enzyme has been redesigned to …

In chemical terms, the regio-and stereoselective hydroxylation of hydrocarbon CH bonds is a
very difficult transformation. Nevertheless, these reactions are deftly catalyzed by a variety of …

Cytochrome P450 monooxygenases (P450s) are versatile biocatalysts that catalyze the
regio-and stereospecic oxidation of non-activated hydrocarbons under mild conditions …

While rust is an unwanted oxidation reaction, there are also many other useful oxidation
reactions that are extremely important and number among the most commonly used …

The development of catalytic systems for the controlled oxidation of C–H bonds remains a
highly sought-after goal in chemistry owing to the great utility of such transformation toward …

Protein engineering of cytochrome P450 monooxygenases (P450s) has been very
successful in generating valuable non-natural activities and properties, allowing these …

Although catalytic reductions, cross‐couplings, metathesis, and oxidation of C C double
bonds are well established, the corresponding catalytic hydroxylations of C H bonds in …

The class of oxidoreductases, to which belong all enzymes catalyzing oxidoreduction
reactions, includes several groups of biocatalysts such as dehydrogenases …

The selective oxyfunctionalization of isolated sp3 C–H bonds in complex molecules
represents a formidable challenge in organic chemistry. Here, we describe a rational …