Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that
involves multiple anatomical sites. Once HSC precursors have been specified from …

Blood cells are constantly produced in the bone marrow (BM) of adult mammals. This
constant turnover ultimately depends on a rare population of progenitors that displays self …

The factors that influence nanoparticle fate in vivo following systemic delivery remain an
area of intense interest. Of particular interest is whether labeling with a cancer-specific …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

The ability to target gene deletion to a specific cellular compartment via the Cre/loxP system
has been a powerful tool in the analysis of broadly expressed genes. Here, we report the …

Tumors build vessels by cooption of pre-existing vasculature and de novo recruitment of
bone marrow (BM)-derived endothelial progenitor cells (EPCs). However, the contribution …

Elucidating the mechanisms underlying hematopoietic stem cell (HSC) specification and
expansion in the embryo has been hampered by the lack of analytical cell culture systems …

Homeodomain proteins of the Meis subfamily are expressed dynamically in several organs
during embryogenesis and exert potent regulatory activity through their interaction with Hox …

The potential of CD31 as a therapeutic target in atherosclerosis has been considered ever
since its cloning in the 1990s, but the exact role played by this molecule in the biologic …

Ex vivo expansion of hematopoietic stem cells (HSCs) is important for many clinical
applications, and knowledge of the surface phenotype of ex vivo–expanded HSCs will be …