Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …

S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in
metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group …

Induction of cell death represents a primary goal of most anticancer treatments. Despite the
efficacy of such approaches, a small population of “persisters” develop evasion strategies to …

4-Hydroxy pyridones are a class of fungi-derived polyketide–nonribosomal peptide products
featuring a core of 4-hydroxy-2-pyridone which have a wide range of biological activities …

Liver cancer is a severe concern for public health officials since the clinical cases are
increasing each year, with an estimated 5-year survival rate of 30%–35% after diagnosis …

Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins, which have a low molecular weight, making them penetrate cells easily …

Hepatocellular carcinoma (HCC), one of the most common lethal diseases in the world, has
a 5-year survival rate of only 7%. Hepatocellular carcinoma has no symptoms in the early …

The endolysin EFm1 from the E. faecalis 002 (002) phage IME-EF1 efficiently lyses E.
faecalis, a gram-positive bacterium that severely threatens human health. Here, the structure …

Endoplasm reticulum stress and inflammation response have been found to be linked to
cerebral ischemia‐reperfusion (IR) injury. Sphingosine kinase 1 (SPHK1) has been reported …

Abstract S‐adenosyl‐L‐methionine (SAM)‐dependent methyltransferases (MTases) are
widely distributed among almost all organisms and often characterized with conserved …