Skeletal muscle energy metabolism during exercise

M Hargreaves, LL Spriet - Nature metabolism, 2020 - nature.com
The continual supply of ATP to the fundamental cellular processes that underpin skeletal
muscle contraction during exercise is essential for sports performance in events lasting …

AMP-activated protein kinase: the current landscape for drug development

GR Steinberg, D Carling - Nature reviews Drug discovery, 2019 - nature.com
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

[HTML][HTML] AMPK in skeletal muscle function and metabolism

R Kjøbsted, JR Hingst, J Fentz, M Foretz… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

AMPK: an energy-sensing pathway with multiple inputs and outputs

DG Hardie, BE Schaffer, A Brunet - Trends in cell biology, 2016 - cell.com
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …

Treatment of nonalcoholic fatty liver disease: role of AMPK

BK Smith, K Marcinko, EM Desjardins… - American Journal …, 2016 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake

EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

The regulation of fat metabolism during aerobic exercise

A Muscella, E Stefàno, P Lunetti, L Capobianco… - Biomolecules, 2020 - mdpi.com
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …

Physiological adaptations to low‐volume, high‐intensity interval training in health and disease

MJ Gibala, JP Little, MJ MacDonald… - The Journal of …, 2012 - Wiley Online Library
Exercise training is a clinically proven, cost‐effective, primary intervention that delays and in
many cases prevents the health burdens associated with many chronic diseases. However …

AMPK in health and disease

GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

The role of AMPK in the regulation of skeletal muscle size, hypertrophy, and regeneration

DM Thomson - International journal of molecular sciences, 2018 - mdpi.com
AMPK (5'-adenosine monophosphate-activated protein kinase) is heavily involved in
skeletal muscle metabolic control through its regulation of many downstream targets …