The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Metabolic reprogramming toward glycolysis is a hallmark of cancer malignancy. The
molecular mechanisms by which the tumor glycolysis pathway promotes immune evasion …

Abstract Treatment with immune checkpoint inhibitors, widely known as immune checkpoint
blockade therapy (ICBT), is now the fourth pillar in cancer treatment, offering the chance of …

The genetic circuits that allow cancer cells to evade immune killing via epithelial
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like …

Abstract Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and
tumorigenesis. Linear ubiquitin chain assembly complex (LUBAC), the only known ubiquitin …

Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been
systematically studied whether there are regulators that uniquely or broadly contribute to T …

Copper (Cu) is an essential element of organisms, which can affect the survival of cells.
However, the role of copper metabolism and cuproptosis on hepatic carcinoma is still …

Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail
polyubiquitin chain to a substrate protein. Early studies found that linear ubiquitin chains are …

The human mammary gland represents a highly organized and dynamic tissue, uniquely
characterized by postnatal developmental cycles. During pregnancy and lactation, it …

CRISPR screen technology enables systematic and scalable interrogation of gene function
by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer …