[HTML][HTML] Emerging roles of oxidative stress in brain aging and Alzheimer's disease

A Ionescu-Tucker, CW Cotman - Neurobiology of aging, 2021 - Elsevier
Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

DL0410 Alleviates Memory Impairment in D‐Galactose‐Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF‐κB Pathway

B Zhang, W Lian, J Zhao, Z Wang… - … Medicine and Cellular …, 2021 - Wiley Online Library
Oxidative stress and neuroinflammation have been demonstrated to be linked with
Alzheimer's disease (AD). In this study, we examined the protective effects of DL0410 in …

Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies

MF Almeida, KLG Farizatto, RS Almeida… - Ageing Research …, 2024 - Elsevier
Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition,
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …

Physical activity vs. redox balance in the brain: brain health, aging and diseases

P Sutkowy, A Woźniak, C Mila-Kierzenkowska… - Antioxidants, 2021 - mdpi.com
It has been proven that physical exercise improves cognitive function and memory, has an
analgesic and antidepressant effect, and delays the aging of the brain and the development …

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

EMS Silveira, A Kroth, MCQ Santos… - Brazilian Journal of …, 2019 - SciELO Brasil
The present study aimed to analyze age-related changes to motor coordination, balance,
spinal cord oxidative biomarkers in 3-, 6-, 18-, 24-, and 30-month-old rats. The effects of low …

Antioxidant molecular brain changes parallel adaptive cardiovascular response to forced running in mice

C Bartra, LA Jager, A Alcarraz, A Meza-Ramos… - Antioxidants, 2022 - mdpi.com
Physically active lifestyle has huge implications for the health and well-being of people of all
ages. However, excessive training can lead to severe cardiovascular events such as heart …

Modifiable Lifestyle Factors and Cognitive Function: A Population‐Based Study Amongst Nondemented Men

KB Corney, AL Stuart, M Mohebbi… - Acta Neurologica …, 2024 - Wiley Online Library
Background: As cognitive decline and dementia‐related diseases are currently incurable,
identifying modifiable and preventative factors is imperative. Thus, we aimed to investigate …

Effect of endurance training with coriander seed consumption on caspase-3 and cytochrome-C in the heart tissue of H2O2-poisoned rats

Z Mardani, SA Hosseini, H Matinhomaee… - Modern Care …, 2020 - brieflands.com
Background: Oxidative stress is a process created by free radicals at the cellular level and
can lead to structural damage in different parts of the cell. However, training (T) and …

The proteasome beta 5 subunit is essential for sexually divergent adaptive homeostatic responses to oxidative stress in D. melanogaster

LCD Pomatto, C Sisliyan, S Wong, M Cline… - Free Radical Biology …, 2020 - Elsevier
Our studies center on the physiological phenomenon of adaptive homeostasis in which very
low, signaling levels of an oxidant can induce transient expansion of the baseline …