Thiadiazole–A promising structure in design and development of anti-Alzheimer agents
M Hatami, Z Basri, BK Sakhvidi, M Mortazavi - International …, 2023 - Elsevier
The design and development of effective multitargeted agents in treating Alzheimer disease
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
Synthetic molecules as P2X7 receptor antagonists: A medicinal chemistry update focusing the therapy of inflammatory diseases
Stimulation of the P2X7 receptor by extracellular adenosine 5'-triphosphate induces a series
of responses in the organism, exceptionally protein cascades related to the proinflammatory …
of responses in the organism, exceptionally protein cascades related to the proinflammatory …
[HTML][HTML] Development of novel montmorillonite-based sustained release system for oral bromopride delivery.
ML Bello, AM Junior, CA Freitas, MLA Moreira… - European Journal of …, 2022 - Elsevier
The drug delivery systems are an important strategy of pharmaceutical technology to
modulate undesirable properties, increasing efficacy, and reducing the side effects of active …
modulate undesirable properties, increasing efficacy, and reducing the side effects of active …
Synthesis and pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation
F Calzaferri, P Narros-Fernandez… - Journal of Medicinal …, 2021 - ACS Publications
The ATP-gated P2X7 purinergic receptor (P2X7) is involved in the pathogenesis of many
neurodegenerative diseases (NDDs). Several P2X7 antagonists have been developed …
neurodegenerative diseases (NDDs). Several P2X7 antagonists have been developed …
Ruscogenin ameliorated Sjögren's syndrome by inhibiting NLRP3 inflammasome activation
J He, Y Wang, L Xu, C Xu, Y Zhu, M Xu… - Evidence‐Based …, 2022 - Wiley Online Library
This article investigated the role and the specific mechanism of Ruscogenin in Sjögren's
syndrome (SS). NOD/ShiLtJ mice were treated with Ruscogenin, and acinar cells isolated …
syndrome (SS). NOD/ShiLtJ mice were treated with Ruscogenin, and acinar cells isolated …
[HTML][HTML] Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo
JCC Arruda, NC Rocha, EG Santos… - Biomedicine & …, 2021 - Elsevier
P2X7 receptor promotes inflammatory response and neuropathic pain. New drugs capable
of impairing inflammation and pain-reducing adverse effects extracted from plant extracts …
of impairing inflammation and pain-reducing adverse effects extracted from plant extracts …
P2X7 receptor: the regulator of glioma tumor development and survival
D Matyśniak, V Chumak, N Nowak, A Kukla, L Lehka… - Purinergic …, 2022 - Springer
P2X7 is an ionotropic nucleotide receptor, forming the cation channel upon ATP stimulation.
It can also function as a large membrane pore as well as transmit ATP-dependent signal …
It can also function as a large membrane pore as well as transmit ATP-dependent signal …
Synthesis, biological evaluation and molecular modeling studies of novel 1, 2, 3-triazole-linked menadione-furan derivatives as P2X7 inhibitors
JPS Dos Santos, RCB Ribeiro, JV Faria… - Journal of Bioenergetics …, 2022 - Springer
Abstract The P2X7 receptor (P2X7R) is an ion channel that promotes the passage of ions
through the membrane through brief stimulation once activated by ATP, its endogenous …
through the membrane through brief stimulation once activated by ATP, its endogenous …
Molecular dynamic simulations of full-length human purinergic receptor subtype P2X7 bonded to potent inhibitors
EG Dos Santos, RX Faria, CR Rodrigues… - European Journal of …, 2020 - Elsevier
Among the members of purinergic receptors, the family P2X of ionotropic proteins has the
ion channel subtype P2X7 that show in studies to be an important molecular target for new …
ion channel subtype P2X7 that show in studies to be an important molecular target for new …
[HTML][HTML] In silico and pharmacological study of N, S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response
PAF Pacheco, JV Faria, AC Silva, NL von Ranke… - Biomedicine & …, 2023 - Elsevier
Purinergic receptors are transmembrane proteins responsive to extracellular nucleotides
and are expressed by several cell types throughout the human body. Among all identified …
and are expressed by several cell types throughout the human body. Among all identified …