Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …

Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Simple Summary Glycosylation is one of the most pivotal post-translational modifications on
all types of biomolecules for the formation of glycoproteins, glycolipids, and glycoRNAs in a …

The war against cancer traces back to the signature event half-a-century ago when the US
National Cancer Act was signed into law. The cancer crusade costs trillions with …

Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids
and play key roles in cellular communication and function. The process of sialylation, a form …

Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

Sialic acid (SA), as the ultimate epitope of polysaccharides, can act as a cap at the end of
polysaccharide chains to prevent their overextension. Sialylation is the enzymatic process of …