Platelet physiology

T Gremmel, AL Frelinger III… - Seminars in thrombosis …, 2016 - thieme-connect.com
Platelets are the smallest blood cells, numbering 150 to 350× 10 9/L in healthy individuals.
The ability of activated platelets to adhere to an injured vessel wall and form aggregates was …

[HTML][HTML] Mechanism action of platelets and crucial blood coagulation pathways in hemostasis

MH Periayah, AS Halim, AZM Saad - International journal of …, 2017 - ncbi.nlm.nih.gov
Blood is considered to be precious because it is the basic necessity for health; our body
needs a steady provision of oxygen, supplied via blood, to reach billions of tissues and cells …

Platelets at work in primary hemostasis

K Broos, HB Feys, SF De Meyer, K Vanhoorelbeke… - Blood reviews, 2011 - Elsevier
When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

[HTML][HTML] Regulation of platelet activation and thrombus formation by reactive oxygen species

J Qiao, JF Arthur, EE Gardiner, RK Andrews, L Zeng… - Redox biology, 2018 - Elsevier
Reactive oxygen species (ROS) are generated within activated platelets and play an
important role in regulating platelet responses to collagen and collagen-mediated thrombus …

Adhesion mechanisms in platelet function

ZM Ruggeri, GL Mendolicchio - Circulation research, 2007 - Am Heart Assoc
Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Platelet physiology and thrombosis

RK Andrews, MC Berndt - Thrombosis research, 2004 - Elsevier
Glycoprotein (GP) Ibα of the GPIb-IX–V complex and GPVI bind von Willebrand factor (vWF)
and collagen, respectively, and are critical for the initial interaction of circulating platelets …

[HTML][HTML] Interaction between platelets and endothelium: from pathophysiology to new therapeutic options

M Hamilos, S Petousis… - … diagnosis and therapy, 2018 - ncbi.nlm.nih.gov
Platelets were traditionally considered to purely have a role in the maintenance of
haemostasis. Recently their role in vasomotor function, inflammation and atherosclerosis …

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

L Erpenbeck, MP Schön - Blood, The Journal of the American …, 2010 - ashpublications.org
The general notion that functional platelets are important for successful hematogenous
tumor metastasis has been inaugurated more than 4 decades ago and has since been …

Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding

C Kleinschnitz, M Pozgajova, M Pham, M Bendszus… - Circulation, 2007 - Am Heart Assoc
Background—Ischemic stroke is a frequent and serious disease with limited treatment
options. Platelets can adhere to hypoxic cerebral endothelial cells by binding of their …

An insight into recent advances on platelet function in health and disease

PK Chaudhary, S Kim, S Kim - International journal of molecular sciences, 2022 - mdpi.com
Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …