G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in
hormonal homeostasis and are interesting drug targets for the treatment of several metabolic …

The vasopressin type 2 receptor (V2R) is a critical G protein-coupled receptor (GPCR) for
vertebrate physiology, including the balance of water and sodium ions. It is unclear how its …

The secretin-like class B family of G protein-coupled receptors (GPCRs) are key players in
hormonal homeostasis. Recent structures of various receptors in complex with a variety of …

It is now recognized that G protein–coupled receptors (GPCRs), once considered largely
independent functional units, have a far more diverse molecular architecture. Receptor …

The classical paradigm of G protein-coupled receptor (GPCR) signaling via G proteins is
grounded in a view that downstream responses are relatively transient and confined to the …

Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …

Ectodomain shedding mediated by tumor necrosis factor–α (TNF-α)–converting enzyme
[TACE; also known as ADAM17 (a disintegrin and metalloproteinase 17)] provides an …

Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled
receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the …

Class BG protein-coupled receptors (GPCRs) respond to paracrine or endocrine peptide
hormones involved in control of bone homeostasis, glucose regulation, satiety, and gastro …