The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

Accurate segregation of homologous chromosomes during meiosis depends on the ability of
meiotic cells to promote reciprocal exchanges between parental DNA strands, known as …

To better understand the gene regulatory mechanisms that program developmental
processes, we carried out simultaneous genome-wide measurements of mRNA, translation …

Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …

Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11
initiates a recombination mechanism that promotes synapsis and the subsequent …

Abstract N6-Methyladenosine (m6A), one of the most abundant internal modification of
eukaryotic mRNAs, participates in the post-transcriptional control of gene expression …

The vast majority of eukaryotes possess two DNA recombinases: Rad51, which is
ubiquitously expressed, and Dmc1, which is meiosis-specific. The evolutionary origins of this …

During meiosis, homologous chromosomes must recognize, pair, and recombine with one
another to ensure the formation of inter-homologue crossover events, which, together with …

Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be
triggered by defects in chromosome synapsis and recombination, which involve repair of …

Ensuring balanced distribution of chromosomes in gametes, meiotic recombination is
essential for fertility in most sexually reproducing organisms. The repair of the programmed …