Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family
Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8 …

Recently discovered mechanosensitive Piezo channels emerged as the main molecular
detectors of mechanical forces. The functions of Piezo channels range from detection of …

Serotonergic mechanisms play a central role in migraine pathology. However, the region-
specific effects of serotonin (5-HT) mediated via multiple types of receptors in the nociceptive …

Migraine is a primary headache disorder which has complex neurogenic pathophysiological
mechanisms still requiring full elucidation. The sensory nerves and meningeal mast cell …

Background Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia
suggested the novel molecular candidate for generation of migraine pain. However, the …

Migraine is a complex neurological disorder with a high disability rate. Although the
precipitating factors of migraine remain unclear, previous studies suggest that when there is …

5‐hydroxytryptamine (5‐HT; serotonin) is traditionally considered as a key mediator
implicated in migraine. Multiple 5‐HT receptor subtypes contribute to a variety of region …

Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and
capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation …

The pro-nociceptive role of glutamate in the CNS in migraine pathophysiology is well
established. Glutamate, released from trigeminal afferents, activates second order …

Background Engaging the endocannabinoid system through inhibition of monoacylglycerol
lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids …