Lactoferrin in aseptic and septic inflammation

MS Lepanto, L Rosa, R Paesano, P Valenti, A Cutone - Molecules, 2019 - mdpi.com
Lactoferrin (Lf), a cationic glycoprotein able to chelate two ferric irons per molecule, is
synthesized by exocrine glands and neutrophils. Since the first anti-microbial function …

Challenges and opportunities of deferoxamine delivery for treatment of Alzheimer's disease, Parkinson's disease, and intracerebral hemorrhage

AC Farr, MP Xiong - Molecular pharmaceutics, 2020 - ACS Publications
Deferoxamine mesylate (DFO) is an FDA-approved, hexadentate iron chelator routinely
used to alleviate systemic iron burden in thalassemia major and sickle cell patients. Iron …

Nano carrier drug delivery systems for the treatment of neuropsychiatric disorders: Advantages and limitations

Y Zorkina, O Abramova, V Ushakova, A Morozova… - Molecules, 2020 - mdpi.com
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

[HTML][HTML] Nose-to-brain (N2B) delivery: an Alternative Route for the Delivery of Biologics in the management and treatment of Central Nervous System disorders

EJ Patharapankal, AL Ajiboye, C Mattern, V Trivedi - Pharmaceutics, 2023 - mdpi.com
In recent years, there have been a growing number of small and large molecules that could
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …

Intranasal drug administration in Alzheimer-type dementia: Towards clinical applications

R Taléns-Visconti, JV de Julián-Ortiz, O Vila-Busó… - Pharmaceutics, 2023 - mdpi.com
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain
barrier and systemic adverse effects. Intranasal administration offers a direct route to the …

Recent uses of lipid nanoparticles, cell-penetrating and bioactive peptides for the development of brain-targeted nanomedicines against neurodegenerative disorders

Y Wu, A Angelova - Nanomaterials, 2023 - mdpi.com
The lack of effective treatments for neurodegenerative diseases (NDs) is an important
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …

Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery

KV Krishna, G Wadhwa, A Alexander… - ACS chemical …, 2019 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …

Exploring Curcumin-Loaded Lipid-Based Nanomedicine as Efficient Targeted Therapy for Alzheimer's Diseases

BF Far, M Safaei, A Pourmolaei… - ACS Applied Bio …, 2024 - ACS Publications
Alzheimer's disease (AD) is a neurological condition currently with 47 million people
suffering from it globally. AD might have many reasons such as genetic issues …

Dopamine-loaded lipid based nanocarriers for intranasal administration of the neurotransmitter: A comparative study

A Trapani, E De Giglio, S Cometa, MA Bonifacio… - European Journal of …, 2021 - Elsevier
Both dopamine (DA) loaded Solid Lipid Nanoparticles (SLN) and liposomes (Lip), designed
for intranasal administration of the neurotransmitter as an innovative Parkinson disease …

Application of nanotechnology in neural growth support system

D Saha, GNR Devi, S Ponnusamy… - 2022 IEEE 2nd …, 2022 - ieeexplore.ieee.org
Carbon nanotubes, having their capacity to transmit electric impulses, contact with neurons,
& simulate the neuronal surroundings, have been appealing possibilities for the creation of …