This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, both clinically and from
a molecular standpoint. The advent of next-generation sequencing technologies has …

The proteasome is a highly sophisticated protease complex designed to carry out selective,
efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Hepatitis C virus (HCV) enhances its replication by modulating host cell lipid metabolism.
HCV circulates in the blood in association with lipoproteins. HCV infection is associated with …

There has been limited analysis of the effects of hepatocellular carcinoma (HCC) on liver
metabolism and circulating endogenous metabolites. Here, we report the findings of a …

The cell-cycle regulator p21 Cip1 is degraded by proteasomes independently of
ubiquitination. We now show that degradation of p21 in vivo does not require the 19S …

Given the pandemic spread of the hepatitis C virus (HCV) infection and the metabolic
syndrome (MS), the burden of their interaction is a major public health issue, bound to …

The picture of chronic liver diseases (CLDs) has changed considerably in recent years. One
of them is the increase of non-alcoholic fatty liver disease. More and more CLD patients …

Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular
carcinoma (HCC), but the mechanism underlying this process remains unclear. Because …