Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Conspectus Atropisomeric compounds are found extensively as natural products, as ligands
for asymmetric transition-metal catalysis, and increasingly as bioactive and pharmaceutically …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …

Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …

Carbene insertion reactions initiated with diazo compounds have been widely used to
develop unnatural enzymatic reactions. However, alternative functionalization of diazo …

Phenols and their derivatives are the elementary building blocks for several classes of
complex molecules that play essential roles in biological systems. Nature has devised …

Axial chirality features prominently in molecules of biological interest as well as chiral
catalyst designs, and atropisomeric 2, 2′-biphenols are particularly prevalent …

Covering: 2008 to 2023 This review will describe oxidative phenol coupling as applied in the
total synthesis of natural products. This review covers catalytic and electrochemical methods …

While natural terpenoid cyclases generate complex terpenoid structures via cationic
mechanisms, alternative radical cyclization pathways are underexplored. The metal …