Abstract Human epididymis protein 4 (HE4) has received major attention as a potential
tumor marker in epithelial ovarian cancer; however, evidence of significant overexpression …

Background The application of human epididymis protein 4 (HE4) in diverse health
diseases, especially in cancers, has been extensively studied in recent decades. To …

Objectives Pathologic subtyping of tissue biopsies is the gold standard for the diagnosis of
lung cancer (LC), which could be complicated in cases of eg inconclusive tissue biopsies or …

Liquid biopsies have become of interest as minimally invasive ways to monitor treatment
response in lung cancer patients. Circulating tumor DNA (ctDNA) and protein biomarkers …

Background Increased expression of the human epididymis protein 4 (HE4) was previously
described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown …

Background Human epididymis protein 4 (HE4) had been shown to be an ideal biomarker in
ovarian cancer. However, there were fewer reports on its application in lung cancer. We …

Background and aim Early diagnosis and histological subtyping are important issues in the
management of patients with lung cancer (LC). The aim of this study is to investigate the …

Background: Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic
risk assessment could improve patient outcome. We examined the significance of urinary N …

Lung cancer currently represents a leading cause of cancer death. Substantial progress
achieved in the medical therapy of lung cancer during the last decade has been associated …

Background: The aim of our study was to assess the value of serum human epididymis
protein 4 (HE4) to diagnose lung cancer and provide reliable scientific conclusions to guide …