Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …

Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …

A key challenge in the clinical management and cause of treatment failure of prostate cancer
(PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems that fully …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and developing therapies. Here, we review …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …