Abstract Three-dimensional (3D) printing enables the production of anatomically matched
and patient-specific devices and constructs with high tunability and complexity. It also allows …

Polylactic acid (PLA) is known as one of the greatest promising bioabsorbable and
compostable polyesters with the capability of high molecular weight synthesis. Lactic acid …

Highlights•Traditional drug screening model systems are inadequate.•Organoid-on-a-chip
platforms stand to significantly advance drug and toxicology screening.•A wide variety or …

The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

Polylactic acid (PLA), one of the well-known bioabsorbable and compostable polyesters has
rapidly evolved into a competitive commodity material over the last decades. To provide …

Current practices in drug development have led to therapeutic compounds being approved
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …

Many drugs have progressed through preclinical and clinical trials and have been available–
for years in some cases–before being recalled by the FDA for unanticipated toxicity in …

Successful launch of a commercial drug requires significant investment of time and financial
resources wherein late-stage failures become a reason for catastrophic failures in drug …

Current 3D printing of tissue is restricted by the use of biomaterials that do not recapitulate
the native properties of the extracellular matrix (ECM). These restrictions have thus far …

This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …