HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination

C Evans, CE Jones, AJ Prendergast - The Lancet infectious diseases, 2016 - thelancet.com
The number of infants infected with HIV is declining with the rise in interventions for the
elimination of paediatric HIV infection, but the number of uninfected infants exposed to HIV …

Training the fetal immune system through maternal inflammation—a layered hygiene hypothesis

AC Apostol, KDC Jensen, AE Beaudin - Frontiers in immunology, 2020 - frontiersin.org
Over the last century, the alarming surge in allergy and autoimmune disease has led to the
hypothesis that decreasing exposure to microbes, which has accompanied industrialization …

A meta-analysis assessing all-cause mortality in HIV-exposed uninfected compared with HIV-unexposed uninfected infants and children

AT Brennan, R Bonawitz, CJ Gill, DM Thea… - Aids, 2016 - journals.lww.com
Objective: Conduct a meta-analysis examining differential all-cause mortality rates between
HIV-exposed uninfected (HEU) infants and children as compared with their HIV-unexposed …

The immune system of HIV-exposed uninfected infants

B Abu-Raya, TR Kollmann, A Marchant… - Frontiers in …, 2016 - frontiersin.org
Infants born to human immunodeficiency virus (HIV) infected women are HIV-exposed but
the majority remains uninfected [ie, HIV-exposed uninfected (HEU)]. HEU infants suffer …

Diagnosis and management of community-acquired pneumonia in children: South African Thoracic Society guidelines

DP Moore, S Andronikou, AC Argent… - African Journal of …, 2020 - journals.co.za
Background. Pneumonia remains a major cause of morbidity and mortality amongst South
African children. More comprehensive immunisation regimens, strengthening of HIV …

Effect of HIV-1 exposure and antiretroviral treatment strategies in HIV-infected children on immunogenicity of vaccines during infancy

OE Simani, A Izu, A Violari, MF Cotton, N Van Niekerk… - Aids, 2014 - journals.lww.com
Methods: HIV-uninfected infants born to HIV-infected (HEU) or HIV-uninfected (HUU)
mothers were enrolled in parallel with HIV-infected children with CD4+≥ 25%, who were …

The effect of human immunodeficiency virus and cytomegalovirus infection on infant responses to vaccines: a review

O Falconer, ML Newell, CE Jones - Frontiers in immunology, 2018 - frontiersin.org
The success of prevention of mother to child transmission programs over the last two
decades has led to an increasing number of infants who are exposed to human …

[HTML][HTML] Anti-group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection

K Le Doare, L Allen, B Kampmann, PT Heath, S Taylor… - Vaccine, 2015 - Elsevier
Background HIV-exposed uninfected infants have increased infection risk and mortality
compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of …

Editorial Commentary: New Challenges in the Elimination of Pediatric HIV Infection: The Expanding Population of HIV-Exposed but Uninfected Children

LM Mofenson - Clinical Infectious Diseases, 2015 - academic.oup.com
The discovery that antiretroviral interventions can prevent mother-to-child human
immunodeficiency virus (HIV) transmission during pregnancy, delivery, and more recently …

Altered natural killer cell function in HIV-exposed uninfected infants

C Smith, E Jalbert, V de Almeida, J Canniff… - Frontiers in …, 2017 - frontiersin.org
Objectives HIV-exposed uninfected (HEU) infants have higher rates of severe and fatal
infections compared with HIV-unexposed (HUU) infants, likely due to immune perturbations …