MicroRNAs in cardiac diseases

RMW Colpaert, M Calore - Cells, 2019 - mdpi.com
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

Desmosomes as signaling hubs in the regulation of cell behavior

L Müller, M Hatzfeld, R Keil - Frontiers in cell and developmental …, 2021 - frontiersin.org
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

Animal models to study cardiac arrhythmias

DJ Blackwell, J Schmeckpeper… - Circulation research, 2022 - Am Heart Assoc
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

MicroRNAs in cardiac hypertrophy

N Wehbe, SA Nasser, G Pintus, A Badran… - International journal of …, 2019 - mdpi.com
Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac
hypertrophy, with age. This remodeling, however, is intensified under stress and …

Signaling cascades in the failing heart and emerging therapeutic strategies

X He, T Du, T Long, X Liao, Y Dong… - Signal transduction and …, 2022 - nature.com
Chronic heart failure is the end stage of cardiac diseases. With a high prevalence and a high
mortality rate worldwide, chronic heart failure is one of the heaviest health-related burdens …

Overexpression of miR‐27b‐3p Targeting Wnt3a Regulates the Signaling Pathway of Wnt/β‐Catenin and Attenuates Atrial Fibrosis in Rats with Atrial Fibrillation

X Lv, J Li, Y Hu, S Wang, C Yang, C Li… - … Medicine and Cellular …, 2019 - Wiley Online Library
MicroRNAs (miRNAs) are regarded as a potential method for the treatment of atrial
fibrillation (AF) although its molecular mechanism remains unknown. We found in our …

The influence of diet on microRNAs that impact cardiovascular disease

B Kura, M Parikh, J Slezak, GN Pierce - Molecules, 2019 - mdpi.com
Food quality and nutritional habits strongly influence human health status. Extensive
research has been conducted to confirm that foods rich in biologically active nutrients have a …

Genetic animal models for arrhythmogenic cardiomyopathy

B Gerull, A Brodehl - Frontiers in Physiology, 2020 - frontiersin.org
Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes
right or biventricular cardiomyopathy associated with ventricular arrhythmia. Although it is a …

[HTML][HTML] Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499–5p/APC axis

J Zhou, S Zhang, X Sun, Y Lou, J Bao, J Yu - Journal of pharmacological …, 2021 - Elsevier
Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely
reported to ameliorate diabetes-associated disease. The current study is designed to …

The emerging role of epigenetics in therapeutic targeting of cardiomyopathies

C Pagiatakis, V Di Mauro - International Journal of Molecular Sciences, 2021 - mdpi.com
Cardiomyopathies (CMPs) are a heterogeneous group of myocardial diseases accountable
for the majority of cases of heart failure (HF) and/or sudden cardiac death (SCD) worldwide …