There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

Astrocytes, through their close associations with synapses, can monitor and alter synaptic
function, thus actively controlling synaptic transmission in the adult brain. Besides their …

Astrocytes are now emerging as key participants in many aspects of brain development,
function and disease. In particular, new evidence shows that astrocytes powerfully control …

Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

The establishment of neural circuitry requires vast numbers of synapses to be generated
during a specific window of brain development, but it is not known why the developing …

Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …

Glial proliferation and activation are associated with disease progression in amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar dementia. In this study, we describe a …

Here we report an in vitro model system for studying the molecular and cellular mechanisms
that underlie the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Embryonic …

Neurovascular coupling plays a key role in the pathogenesis of neurodegenerative
disorders including motor neuron disease (MND). In vitro models provide an opportunity to …