Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Microtubules form important cytoskeletal structures that play a role in establishing and
maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and …

Microglia have multiple functions in regulating homeostasis in the central nervous system
(CNS), and microglial inflammation is thought to play a role in the etiology of the …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease,
but the precise physiological function of the protein remains ill-defined. Recently, our group …

It is now well established that chronic inflammation is a prominent feature of several
neurodegenerative disorders including Parkinson's disease (PD). Growing evidence …

Parkinson's disease (PD) is one of the major neurodegenerative diseases (ND) which
presents a progressive neurodegeneration characterized by loss of dopamine in the …

Mutations in LRRK2, encoding the multifunctional protein leucine-rich repeat kinase 2
(LRRK2), are a common cause of Parkinson disease. LRRK2 has been suggested to …

In 2004 it was first shown that mutations in LRRK2 can cause Parkinson's disease. This
initial discovery was quickly followed by the observation that a single particular mutation is a …