The widespread use of pesticides in modern agriculture is of increasing concern due to
environmental contamination and subsequent biodiversity loss. Chlorpyrifos is a toxic …

The etiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. The role of pesticide …

This review examines the large body of toxicological and epidemiological information on
human exposures to chlorpyrifos, with an emphasis on the controversial potential for …

The complexity of neurodevelopment, the rapidity of early neurogenesis, and over 100 years
of research identifying environmental influences on neurodevelopment serve as backdrop to …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Acetylcholine and other neurotransmitters play unique trophic roles in brain development.
Accordingly, drugs and environmental toxicants that promote or interfere with …

Agricultural and residential use of organophosphate (OP) pesticides has increased in recent
decades after banning some persistent pesticides. Although there is evidence of the effects …

Cholinesterase inhibitors have been used in the treatment of human diseases, the control of
insect pests, and more notoriously as chemical warfare agents and weapons of terrorism …

Organochlorine and organophosphate pesticides are compounds that can be detected in
human populations as a result of occupational or residential exposure. Despite their …