Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

Introduction: Numerous clinical and pre-clinical studies have provided ample evidence
supporting that the tumor microenvironment plays a significant role during breast cancer …

Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human
physiology and pathology. CTSB is associated with various human diseases, and its …

Long-acting formulations are designed to reduce dosing frequency and simplify dosing
schedules by providing an extended duration of action. One approach to obtain long-acting …

The high incidence of breast cancer in developed and developing countries, and its
correlation to cancer-related deaths, has prompted concerned scientists to discover novel …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

Metastasis to bone is a major cause of morbidity in breast cancer patients, emphasizing the
importance of identifying molecular drivers of bone metastasis for new therapeutic targets …

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the
treatment of different cancers and other diseases. However, no clinically approved drugs for …

Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …

Background Several studies have found that Cathepsin B (CTSB) is up-regulated in many
tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular …