Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …

IgG4-related disease is a protean condition that mimics many malignant, infectious, and
inflammatory disorders. This multi-organ immune-mediated condition links many disorders …

The complex interactions between tumors and their microenvironment remain to be
elucidated. Combining large-scale approaches, we examined the spatio-temporal dynamics …

The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the
history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize …