The gut microbiome plays a crucial role in host health throughout the lifespan by influencing
brain function during aging. The microbial diversity of the human gut microbiome decreases …

Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …

Gut microbiota represents a diverse and dynamic population of microorganisms harbouring
the gastrointestinal tract, which influences host health and disease. Bacterial colonization of …

Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

Metabolism and nutrition have a significant role in epigenetic modifications such as DNA
methylation, which can influence gene expression. Recently, it has been suggested that …

In the central nervous system (CNS), glial cells, such as microglia and astrocytes, are
normally associated with support roles including contributions to energy metabolism …

Background An active lifestyle is associated with improved cognitive functions in aged
people and may prevent or slow down the progression of various neurodegenerative …

Mechanisms linking intestinal bacteria and neurodegenerative diseases such as
Alzheimer's disease (AD) are still unclear. We hypothesized that intestinal dysbiosis might …

Education, occupation, and an active lifestyle, comprising enhanced social, physical, and
mental components are associated with improved cognitive functions in aged people and …