Background: A full understanding of the mechanisms of action of aldosterone and its
interaction with the mineralocorticoid receptor (MR) allows a theoretical framework to predict …

Blood is made up of leukocytes (WBCs), erythrocytes (RBCs), and thrombocytes. The ratio of
blood cancer diseases is increasing rapidly, among which leukemia is one of the famous …

White blood cells (WBCs) are a portion of the immune system which fights against germs.
Leukemia is the most common blood cancer which may lead to death. It occurs due to the …

The recent successful demonstrations that the nonsteroidal mineralocorticoid receptor (MR)
antagonist finerenone provides effective kidney and cardiovascular (CV) protection in …

Clinical and genetic factors have been reported as influencing the development of sickle cell
nephropathy (SCN). However, such data remain limited in the paediatric population. In this …

People with sickle cell disease (SCD) are at greater risk of severe illness and death from
respiratory infections, including COVID-19, than people without SCD (Centers for Disease …

One of the major chronic complications of sickle cell disease (SCD) is sickle cell
nephropathy. The aim of this review is to discuss the pathophysiology, natural history …

Patients with sickle cell disease (SCD) who undergo repeated blood transfusions often
develop iron overload. Deferiprone (Ferriprox®) is an oral iron chelator indicated for the …

Background Little is known on how the interaction between Sickle Cell Disease (SCD) and
renal insults caused by other coexisting conditions in Sub Saharan Africa such as urinary …

Background: Sickle cell disease commonly presents with unpredictable episodes of
vasocclusion and pre mature RBC destruction, which manifest as acute pain and tissue …