China has approximately 10 million people with epilepsy. There is a vast epilepsy treatment
gap in China, mainly driven by deficiencies in health-care delivery and social discrimination …

Epilepsy is a serious, potentially life shortening brain disorder, the symptoms of which can
be successfully treated in most patients with one or more antiepileptic drug. About two in …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening
mucocutaneous reactions, predominantly drug induced. The mortality rates for SJS and TEN …

Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large
interpatient variability, partly due to genetic variations in the gene encoding cytochrome …

Importance Approximately 8% to 10% of the population will experience a seizure during
their lifetime. Only about 2% to 3% of patients go on to develop epilepsy. Understanding the …

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening
diseases characterized by detachment of the epidermis and mucous membrane. SJS/TEN …

Objective To systematically review evidence on genetic risk factors for carbamazepine (CBZ)–
induced hypersensitivity reactions (HSR s) and provide practice recommendations …

Individuals differ substantially in their response to pharmacological treatment. Personalized
medicine aspires to embrace these inter-individual differences and customize therapy by …