Collagen-and hyaluronic acid-based hydrogels and their biomedical applications

Q Xu, JE Torres, M Hakim, PM Babiak, P Pal… - Materials Science and …, 2021 - Elsevier
Hydrogels have been widely investigated in biomedical fields due to their similar physical
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …

[HTML][HTML] Hyaluronic acid and its biomedical applications: A review

M Dovedytis, ZJ Liu, S Bartlett - Engineered Regeneration, 2020 - Elsevier
Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within
the body including wound repair, cell migration, and cell signaling. Due to its versatility …

Hyaluronan: metabolism and function

T Kobayashi, T Chanmee, N Itano - Biomolecules, 2020 - mdpi.com
As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential
roles in the organization of tissue architecture and the regulation of cellular functions, such …

Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer

AG Tavianatou, I Caon, M Franchi… - The FEBS …, 2019 - Wiley Online Library
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Ceria nanozyme-integrated microneedles reshape the perifollicular microenvironment for androgenetic alopecia treatment

A Yuan, F Xia, Q Bian, H Wu, Y Gu, T Wang, R Wang… - ACS …, 2021 - ACS Publications
Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective
treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen …

Structure, substrate recognition and initiation of hyaluronan synthase

FP Maloney, J Kuklewicz, RA Corey, Y Bi, R Ho… - Nature, 2022 - nature.com
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine
and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular …

Extracellular matrix mimics using hyaluronan-based biomaterials

S Amorim, CA Reis, RL Reis, RA Pires - Trends in Biotechnology, 2021 - cell.com
Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated
synthesis and degradation of HA modulates the ECM chemical and physical properties that …

Biomaterials and 3D bioprinting strategies to model glioblastoma and the blood–brain barrier

M Tang, JN Rich, S Chen - Advanced Materials, 2021 - Wiley Online Library
Glioblastoma (GBM) is the most prevalent and lethal adult primary central nervous system
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …

[HTML][HTML] Viscoelastic properties of hyaluronan in physiological conditions

MK Cowman, TA Schmidt, P Raghavan… - F1000Research, 2015 - ncbi.nlm.nih.gov
Hyaluronan (HA) is a high molecular weight glycosaminoglycan of the extracellular matrix
(ECM), which is particularly abundant in soft connective tissues. Solutions of HA can be …

Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins

A Vedadghavami, C Zhang, AG Bajpayee - Nano today, 2020 - Elsevier
Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …