Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …

Mental disorders are increasingly conceptualized as biomedical diseases, explained as
manifestations of genetic and neurobiological abnormalities. Here, we discuss changes in …

Objective: The Treatment-Resistant Depression Registry investigated whether adjunctive
vagus nerve stimulation (VNS) with treatment as usual in depression has superior long-term …

Internet-and mobile-based interventions (IMI) offer an effective way to complement health
care. Acceptance of IMI, a key facilitator of their implementation in routine care, is often low …

Background Conventional pharmacotherapies and psychotherapies for major depression
are associated with limited adherence to care and relatively low remission rates. Yoga may …

Background Technological progress in artificial intelligence has led to the increasing
popularity of virtual assistants, ie, embodied or disembodied conversational agents that …

Background Pharmacogenomic testing has recently become scalable and available to guide
the treatment of major depressive disorder (MDD). The objective of the current meta-analysis …

Objective: Previous research has shown that biological (eg, genetic, biochemical) accounts
of depression—currently in ascendancy—are linked to the general public's pessimism about …

The mind is a powerful anticipatory device. It frequently makes predictions about the future,
telling us not only how the world might or will be, but also how it should be-or better-how we …

Although the chemical imbalance theory is the dominant causal explanation of depression in
the United States, little is known about the effects of this explanation on depressed …