Parkinson's disease (PD) is becoming prevalent with the increasingly ageing global
population. PD is a multi-factorial disease for which there is currently no cure but only …

The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in
neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's …

Parkinson's disease (PD) is a movement disorder characterized by the early loss of
nigrostriatal dopaminergic pathways producing significant network changes impacting motor …

Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons
which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the …

Mitochondria are highly dynamic organelles with strict quality control processes that
maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated …

The huntingtin (HTT) protein transports various organelles, including vesicles containing
neurotrophic factors, from embryonic development throughout life. To better understand how …

α-synuclein (α-syn) is a presynaptic, lipid-binding protein strongly associated with the
neuropathology observed in Parkinson's disease (PD), dementia with Lewy bodies (DLB) …

A wide range of biophysical and theoretical analysis were employed to explore the formation
of (α-syn) amyloid fibril formation as a model of Parkinson's disease in the presence of silica …

Accumulation of α-Synuclein (αSyn) in nigral dopaminergic neurons is commonly seen in
patients with Parkinson′ s disease (PD). We recently reported that transduction of …

Parkinson's disease (PD) is a complex neurodegenerative disease characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …