Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …

The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is
associated with poor clinical outcome following traumatic brain injury and other …

Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …

Oxidative stress, manifested by protein oxidation, lipid peroxidation, DNA oxidation and 3-
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …

APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with
amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ …

Inheritance of the apoE4 allele (ε4) increases the risk of developing Alzheimer's disease;
however, the mechanisms underlying this association remain elusive. Recent data suggest …

To investigate the role of human apolipoprotein E (apoE) on Aβ deposition in vivo, we
crossed PDAPP mice lacking mouse Apoe to targeted replacement mice expressing human …

The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for
Alzheimer's disease (AD), but limited work has suggested that APOE genotype may …