A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Background: Recent pathologic investigations have shown that neocortical lesions are
frequent in multiple sclerosis (MS). Structural MRI has shown that neocortical atrophy occurs …

Multiple sclerosis (MS) is commonly regarded as an inflammatory disease, but it also has a
neurodegenerative component, which represents an additional target for treatment. The use …

Increasing numbers of drugs are being developed for the treatment of multiple sclerosis
(MS). Measurement of relevant outcomes is key for assessing the efficacy of new drugs in …

The measurement of brain metabolites with magnetic resonance spectroscopy (MRS)
provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context …

Traumatic brain injury (TBI) remains a serious health concern, and TBI is one of the leading
causes of death and disability, especially among young adults. Although preventive …

Background Recombinant interferons have been approved by many national regulatory
agencies for treatment of relapsing remitting multiple sclerosis, but widespread discussion …

MRI has become the most important paraclinical tool for diagnosing and monitoring patients
with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific …