Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis
M Varela-Eirin, J Loureiro, E Fonseca… - Ageing research …, 2018 - Elsevier
Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …
This prototypic degenerative condition of ageing is the most common form of arthritis and is …
The extracellular matrix of articular cartilage controls the bioavailability of pericellular matrix-bound growth factors to drive tissue homeostasis and repair
TL Vincent, O McClurg, L Troeberg - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) has long been regarded as a packing material; supporting
cells within the tissue and providing tensile strength and protection from mechanical stress …
cells within the tissue and providing tensile strength and protection from mechanical stress …
Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of …
X Liu, L Wang, C Ma, G Wang, Y Zhang… - Journal of orthopaedic …, 2019 - Springer
Background Platelet-rich plasma (PRP) provides a nonsurgical approach for treating
osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been …
osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been …
Engineering zonal cartilage through bioprinting collagen type II hydrogel constructs with biomimetic chondrocyte density gradient
X Ren, F Wang, C Chen, X Gong, L Yin… - BMC musculoskeletal …, 2016 - Springer
Background Cartilage tissue engineering is a promising approach for repairing and
regenerating cartilage tissue. To date, attempts have been made to construct zonal cartilage …
regenerating cartilage tissue. To date, attempts have been made to construct zonal cartilage …
Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways
H Qi, DP Liu, DW Xiao, DC Tian, YW Su… - In Vitro Cellular & …, 2019 - Springer
Osteoarthritis (OA) is the most common chronic joint disease worldwide. Chondrocyte, as the
only resident cell type in cartilage, its apoptosis is of pathogenetic significance in OA …
only resident cell type in cartilage, its apoptosis is of pathogenetic significance in OA …
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
M Varela-Eirín, A Varela-Vázquez… - Cell death & …, 2018 - nature.com
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …
Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p
Z Zhou, D Du, G Huang, A Chen, L Zhu - Gene, 2018 - Elsevier
Osteoarthritis (OA) is the most common joint disease and is mainly characterized by
degradation of the articular cartilage. Recently, circular RNAs (circRNAs), novel noncoding …
degradation of the articular cartilage. Recently, circular RNAs (circRNAs), novel noncoding …
[图书][B] Articular cartilage
This book covers the latest research and advancements related to articular cartilage in
biology, development, pathology, clinical applications and tissue engineering. The authors …
biology, development, pathology, clinical applications and tissue engineering. The authors …
IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway
D Guo, S Kan, L Zhang, Z Niu, M Duan, Y Liu, X Pu… - Cellular …, 2023 - Elsevier
Gap junction intercellular communication (GJIC) allows the transfer of material, message
and energy between cells, which influences cell behaviors including cell proliferation …
and energy between cells, which influences cell behaviors including cell proliferation …
Direct cell–cell contact with chondrocytes is a key mechanism in multipotent mesenchymal stromal cell-mediated chondrogenesis
TS de Windt, DBF Saris… - … Engineering Part A, 2015 - liebertpub.com
Using a combination of articular chondrocytes (ACs) and mesenchymal stromal cells (MSCs)
has shown to be a viable option for a single-stage cell-based treatment of focal cartilage …
has shown to be a viable option for a single-stage cell-based treatment of focal cartilage …