Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …
Engineered nanomedicines with enhanced tumor penetration
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
Smart transformable nanoparticles for enhanced tumor theranostics
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …
influence their biological behaviors. In the past, nanoparticles with constant physical …
Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.
A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on
albumin-coated MnO2 is presented, which is capable of modulating the tumor …
albumin-coated MnO2 is presented, which is capable of modulating the tumor …
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids
AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …
Targeted nanomedicine in cisplatin-based cancer therapeutics
Since its license in 1978, cisplatin has proved to be one of the most successful
chemotherapeutic agents in the world. However, two acute challenges facing cisplatin …
chemotherapeutic agents in the world. However, two acute challenges facing cisplatin …
Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics
Z Wang, Y Ju, Z Ali, H Yin, F Sheng, J Lin… - Nature …, 2019 - nature.com
Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the
field of theranostics. However, developing SDDSs with early diagnostic capability, enhanced …
field of theranostics. However, developing SDDSs with early diagnostic capability, enhanced …
Multicellular tumor spheroids (MCTS) as a 3D in vitro evaluation tool of nanoparticles
H Lu, MH Stenzel - Small, 2018 - Wiley Online Library
Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can
mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano …
mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano …
Crossing biological barriers with nanogels to improve drug delivery performance
JC Cuggino, ERO Blanco, LM Gugliotta… - Journal of Controlled …, 2019 - Elsevier
The current limitations in the use of nanocarriers to treat constantly evolving diseases call for
the design of novel and smarter drug delivery systems (DDS). Nanogels (NGs) are three …
the design of novel and smarter drug delivery systems (DDS). Nanogels (NGs) are three …
Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines
G Lazzari, P Couvreur, S Mura - Polymer Chemistry, 2017 - pubs.rsc.org
The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …