Pyrimidines have become an increasingly important core structure in many drug molecules
over the past 60 years. This article surveys recent areas in which pyrimidines have had a …

Tuberculosis (TB) is a global issue that poses a significant economic burden as a result of
the ongoing emergence of drug-resistant strains. The urgent requirement for the …

In this study, we designed and synthesized a series of coumarin derivatives as
antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme …

Diabetes mellitus, a prevalent metabolic disorder, necessitates continuous exploration for
innovative therapeutic agents. Indolinedione has garnered attention for its potential as an …

Because resistant variants of the disease are always emerging, tuberculosis is a global
issue that affects economies. New antitubercular medications should be developed, and this …

Tuberculosis is a global serious problem that imposes major health, economic and social
challenges worldwide. The search for new antitubercular drugs is extremely important which …

Bacterial infection poses a serious threat to human life due to the rapidly growing resistance
of bacteria to antibacterial drugs, which is a significant public health issue. This study was …

This investigation employed computational methodologies to assess the therapeutic
potential of derivatives (1–16) of pyridoxal isonicotinoyl hydrazone (PIH) as potential …

Antibiotic resistance, particularly against fluoroquinolones and macrolides, has emerged
globally among thermophilic Campylobacters (Campylobacter jejuni and Campylobacter …

Bacterial infection poses a serious threat to human life due to its rapidly growing resistance
to antibacterial drugs, which is a significant public health issue. This study was focused on …