The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is
coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear …

Tear film lipid layer (TFLL) stabilizes the air/tear surface of the human eye. Meibomian gland
dysfunction (MGD) resulting in quantitative and qualitative modifications of TFLL major (> …

This review critically evaluates a broad range of literature in order to show the relationship
between meibum, tear lipids and the tear film lipid layer (TFLL). The relationship of meibum …

Great strides have recently been made in quantitative measurements of tear film thickness
and thinning, mathematical modeling thereof and linking these to sensory perception. This …

Dry eye disease (DED) has become common on a global scale in recent years. There is a
wide prevalence of DED in different countries based on various ethnicities and environment …

Abstract On March 21, 2015, a meeting was held in London, United Kingdom, to address the
progress in targeting the unmet need for dry eye disease (DED) treatment. The meeting …

Although most mammalian fatty acids (FAs) are straight-chain, there also exist branched-
chain FAs such as iso-and anteiso-FAs, especially in the meibomian glands. Meibum lipids …

Tear film breakup (BU) is an important aspect of dry eye disease, as a cause of ocular
aberrations, irritation and ocular surface inflammation and disorder. Additionally …