Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment

B Wu, X Shi, M Jiang, H Liu - Molecular Cancer, 2023 - Springer
Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

IDO/kynurenine pathway in cancer: possible therapeutic approaches

EE Abd El-Fattah - Journal of Translational Medicine, 2022 - Springer
Cancer is one of the leading causes of death in both men and women worldwide. One of the
main changes associated with cancer progression, metastasis, recurrence, and …

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

RS Laureano, J Sprooten, I Vanmeerbeerk… - …, 2022 - Taylor & Francis
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …

Research progress on dendritic cell vaccines in cancer immunotherapy

J Yu, H Sun, W Cao, Y Song, Z Jiang - Experimental hematology & …, 2022 - Springer
Dendritic cell (DC) vaccines induce specific immune responses that can selectively
eliminate target cells. In recent years, many studies have been conducted to explore DC …

[HTML][HTML] The role of stem cells in small-cell lung cancer: evidence from chemoresistance to immunotherapy

W Guo, T Qiao, T Li - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, accounting for
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …

[HTML][HTML] The complex network of transcription factors, immune checkpoint inhibitors and stemness features in colorectal cancer: A recent update

M Merhi, F Ahmad, N Taib, V Inchakalody… - Seminars in Cancer …, 2023 - Elsevier
Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …

Role of intracellular iron in switching apoptosis to ferroptosis to target therapy-resistant cancer stem cells

SL Pandrangi, P Chittineedi, SS Chalumuri, AS Meena… - Molecules, 2022 - mdpi.com
Iron is a crucial element required for the proper functioning of the body. For instance,
hemoglobin is the vital component in the blood that delivers oxygen to various parts of the …

Benzo [a] pyrene immunogenetics and immune archetype reprogramming of lung

EE Abd El-Fattah, AM Abdelhamid - Toxicology, 2021 - Elsevier
Overexposure to carcinogenic precursor, benzo [a] pyrene [BaP], modulates the lung
immune microenvironment. The present review seeks to elucidate novel pathways behind …

[HTML][HTML] Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application

AM Abdelhamid, S Saber, ME Youssef… - Biomedicine & …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is on the rise worldwide, and its incidence in diabetic
patients is two to three times that of non-diabetics. Current therapeutic options fail to provide …

Metformin modulate immune fitness in hepatocellular carcinoma: Molecular and cellular approach

EE Abd El-Fattah, AY Zakaria - International Immunopharmacology, 2022 - Elsevier
Hyperinsulinemia, hyperglycemia, and chronic inflammation may play a role in
hepatocellular carcinoma (HCC). Treatment of HCC patients with the antidiabetic medication …