In this retrospective, we review the two research topics that formed the basis of the
outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease …

Thrombosis is one of the leading causes of death worldwide. As such, it also occurs as one
of the major complications in hemolytic diseases, like hemolytic uremic syndrome …

Previous studies have reported elevated von Willebrand factor (VWF) levels in patients with
sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the …

Although patients with homozygous sickle cell anemia (SCA) carry both significant left atrial
(LA) remodeling and an increased risk of stroke, the prevalence of atrial arrhythmia (AA) has …

Thrombosis within the microvasculature and medium to large vessels is a serious and
common complication among critically ill individuals with coronavirus disease 2019 (COVID …

Microvascular vaso-occlusion driven pain crisis is the hallmark of sickle cell disease with
profound morbidity and increased mortality. Selectins, most notably P-selectins have an …

Beta (β)‐thalassemia and sickle cell disease (SCD) are characterized by a hypercoagulable
state, which can significantly influence organ complication and disease severity. While red …

Iron deficiency anemia has a high prevalence in children and has repeatedly been
implicated as a risk factor for arterial and venous thrombosis. As an effective therapy for iron …

Prototype of monogenic disorder, sickle cell disease (SCD) is caused by a unique single
mutation in the β-globin gene, leading to the production of the abnormal hemoglobin S …

Venous thromboembolism (VTE) is a life-threatening complication observed among patients
with sickle cell disease (SCD) and also among those with severe COVID-19 infection …