Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

We propose that several chromatin-mediated regulatory processes are dominated by source-
sink relationships in which factors operate as 'sources' to produce or provide a resource and …

Craniofacial anomalies, especially midline facial defects, are among the most common birth
defects in patients and are associated with increased mortality or require lifelong treatment …

Highlights•Pioneer factors and histones prime the chromatin landscape for zygotic
transcription.•ZGA timing is regulated by nuclear-to-cytoplasmic (N/C) ratio and cell cycle …

Quantitative live imaging is a valuable tool that offers insights into cellular dynamics.
However, many fundamental biological processes are incompatible with current live …

Mutations in SETD2 are among the most prevalent drivers of renal cell carcinoma (RCC).
We identified a novel single nucleotide polymorphism (SNP) in SETD2, E902Q, within a …

The ratio of nuclear content to cytoplasmic volume (N/C ratio) is a key regulator driving the
maternal-to-zygotic transition in most animal embryos. Altering this ratio often impacts …

Early embryos often have relatively unstructured chromatin that lacks active and inactive
domains typical of differentiated cells. In many species, these regulatory domains are …

Early embryos often have relatively unstructured chromatin that lacks active and inactive
domains typical of differentiated cells. In many species, these regulatory domains are …

Quantitative live imaging is a valuable tool that offers insights into cellular dynamics.
However, many fundamental biological processes are incompatible with current live imaging …