Asthma epidemiology and risk factors

J Stern, J Pier, AA Litonjua - Seminars in immunopathology, 2020 - Springer
Asthma is a clinical syndrome that affects all age groups. Asthma prevalence worldwide has
seen a rapid increase in the latter part of the last century. Recent data has shown that …

Pyroptosis, metabolism, and tumor immune microenvironment

T Du, J Gao, P Li, Y Wang, Q Qi, X Liu… - Clinical and …, 2021 - Wiley Online Library
In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

M Depner, DH Taft, PV Kirjavainen, KM Kalanetra… - Nature medicine, 2020 - nature.com
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

[HTML][HTML] GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

N Rana, G Privitera, HC Kondolf, K Bulek, S Lechuga… - Cell, 2022 - cell.com
Gasdermins are a family of structurally related proteins originally described for their role in
pyroptosis. Gasdermin B (GSDMB) is currently the least studied, and while its association …

Cellular and molecular mechanisms of allergic asthma

ZI Komlósi, W van de Veen, N Kovács, G Szűcs… - Molecular aspects of …, 2022 - Elsevier
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Viral bronchiolitis in children

HC Meissner - New England Journal of Medicine, 2016 - Mass Medical Soc
Viral Bronchiolitis in Children | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH The New England Journal …

The immunology of asthma

BN Lambrecht, H Hammad - Nature immunology, 2015 - nature.com
Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …

Role of viral infections in the development and exacerbation of asthma in children

T Jartti, JE Gern - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory
syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV) is …

Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium

SP Sajuthi, P DeFord, Y Li, ND Jackson… - Nature …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging
virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the …

Sphingolipid metabolites in inflammatory disease

M Maceyka, S Spiegel - Nature, 2014 - nature.com
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …