Iron is a critical element for living cells in terrestrial life. Although iron metabolism is strictly
controlled in the body, disturbance of iron homeostasis under certain type of condition leads …

Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …

Cancer stem cells (CSCs) within protumorigenic microlesions are a critical driver in the
initiation and progression of early stage lung cancer, where immune cells provide an …

As the predominant immunosuppressive component within the tumor microenvironment
(TME), cancer-associated fibroblasts (CAFs) inhibit Natural Killer cell (NK cell) activity to …

Lower-grade glioma (LGG) is characterized by genetic and transcriptional heterogeneity,
and a dismal prognosis. Iron metabolism is considered central for glioma tumorigenesis …

Abstract Microparticles (MPs) are 100–1000 nm heterogeneous submicron membranous
vesicles derived from various cell types that express surface proteins and antigenic profiles …

Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by
dysfunctional inflammatory response. However, no effective therapeutic options have been …

Background Ferroptosis, a new form of programmed cell death, has great potential for
cancer treatment. However, the roles of ferroptosis-related (FR) genes in breast cancer (BC) …

The liver cancer has microenvironmental features such as low pH, M2 tumor-associated
macrophage enrichment, low oxygen, rich blood supply and susceptibility to hematotropic …