Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Failure of regulatory T (Treg) cells to properly control immune responses leads invariably to
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Cell-based immunotherapies can provide safe and effective treatments for various disorders
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …

Autoimmune liver diseases (AILD) include autoimmune hepatitis (AIH), primary biliary
cholangitis (PBC) and primary sclerosing cholangitis (PSC). These immune-mediated liver …

Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in
the immune system. Therefore, restoration of the immune balance represents a promising …

CD8+ Tregs have been long described and significant progresses have been made about
their phenotype, their functional mechanisms, and their suppressive ability compared to …

Abstract Human CD4+ 25− T cells cultured in interleukin 2 (IL-2), rapamycin, and
transforming growth factor β (TGFβ) along with anti-CD3 monoclonal antibody–loaded …

Recently, increased interest in the use of Tregs as adoptive cell therapy for the treatment of
autoimmune diseases and transplant rejection had led to several advances in the field …

Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to
middle-aged adults, affecting~ 2.5 million people worldwide. Currently, most therapeutics for …