Peroxidases are heme proteins which are able to catalyze the oxidization of a large variety
of substrates through the reaction with hydrogen peroxide. The specific biological function …

This review is concerned with the oxidative chemistry of phagocytes (Gk. phagos=
devouring, kytos= container), the motile cells in animals that constitute the primary cellular …

The three-dimensional structure of the enzyme myeloperoxidase has been determined by X-
ray crystallography to 3 Å resolution. Two heavy atom derivatives were used to phase an …

The oxidation of lipoproteins is considered to play a key role in atherogenesis, and tyrosyl
radicals have been implicated in the oxidation reaction. Tyrosyl radicals are generated in a …

A sensitive confocal Raman microspectrometer was employed to record spectra of nuclei
and cytoplasmic regions of single living human granulocytes. Conditions were used that …

Acute lymphoblastic leukemia type B (B-ALL) is a neoplastic disorder that shows high
mortality rates due to immature lymphocyte B-cell proliferation. B-ALL diagnosis requires …

Human myeloperoxidase and human thyroid peroxidase nucleotide and amino acid
sequences were compared. The global similarities of the nucleotide and amino acid …

Covering: 1966 to 2007The mammalian peroxidases myeloperoxidase, eosinophil
peroxidase, lactoperoxidase and thyroid peroxidase participate in host defense against …

The potent myeloperoxidase-hydrogen-peroxide-halide (MPO-H 2 O 2-halide) system
created by activated neutrophils represents an extremely efficient microbicidal system …

Reactive oxygen species (ROS) and iron play important roles in the innate immune
response. ROS are released by immune cells and are highly reactive and indiscriminately …