Role and mechanism of vitamin A metabolism in the pathophysiology of Parkinson's disease

A Marie, M Darricau, K Touyarot… - Journal of …, 2021 - content.iospress.com
Evidence shows that altered retinoic acid signaling may contribute to the pathogenesis and
pathophysiology of Parkinson's disease (PD). Retinoic acid is the bioactive derivative of the …

[HTML][HTML] Metabolism of neonatal vitamin A supplementation: a systematic review

BM Gannon, LM Rogers, SA Tanumihardjo - Advances in Nutrition, 2021 - Elsevier
ABSTRACT A systematic review was conducted to summarize the absorption, transport,
storage, and metabolism of oral neonatal vitamin A supplementation (NVAS). This review …

Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice

IO Shmarakov, GA Gusarova, MN Islam… - Nature …, 2023 - nature.com
Retinoids are potent transcriptional regulators that act in regulating cell proliferation,
differentiation, and other cellular processes. We carried out studies in male mice to establish …

Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats

F Dumetz, C Buré, S Alfos, M Bonneu, E Richard… - Neurobiology of …, 2020 - Elsevier
Dietary micronutrients constitute a major environmental factor influencing aging processes.
Vitamin A (vit. A) is the precursor of retinoic acid, a bioactive molecule that controls the …

Maternal fat-soluble vitamins, brain development, and regulation of feeding behavior: an overview of research

D Sanchez-Hernandez, GH Anderson, AN Poon… - Nutrition Research, 2016 - Elsevier
Recent research shows a link between vitamin intake during pregnancy and offspring
health. Inadequate intakes of water-soluble vitamins during pregnancy lead to obesity and …

[HTML][HTML] Single high-dose vitamin A supplementation to neonatal piglets results in a transient dose response in extrahepatic organs and sustained increases in liver …

BM Gannon, CR Davis, N Nair, M Grahn… - The Journal of …, 2017 - Elsevier
ABSTRACT Background Neonatal vitamin A (VA) supplementation is being evaluated as a
public health policy for preventing infant mortality, but inconsistencies in mortality trials …

[HTML][HTML] Infant rhesus macaque brain α-tocopherol stereoisomer profile is differentially impacted by the source of α-tocopherol in infant formula

MJ Kuchan, KM Ranard, P Dey, S Jeon, GY Sasaki… - The Journal of …, 2020 - Elsevier
Background: α-tocopherol (αT) in its natural form [2´ R, 4´ R, 8´ RαT (RRR-αT)] is more
bioactive than synthetic α-tocopherol (all rac-αT). All rac-αT is widely used in infant formulas …

Retinoic acid promotes tissue vitamin A status and modulates adipose tissue metabolism of neonatal rats exposed to maternal high-fat diet-induced obesity

L Tan, Y Zhang, H Wang, H Haberer - Journal of nutritional science, 2022 - cambridge.org
Maternal obesity may compromise the micronutrient status of the offspring. Vitamin A (VA) is
an essential micronutrient during neonatal development. Its active metabolite, retinoic acid …

[HTML][HTML] Vitamin A supplementation redirects the flow of retinyl esters from peripheral to central organs of neonatal rats raised under vitamin A–marginal conditions

JK Hodges, L Tan, MH Green, AC Ross - The American Journal of Clinical …, 2017 - Elsevier
Abstract Background: Vitamin A (VA; retinol) supplementation is used to reduce child
mortality in countries with high rates of malnutrition. Existing research suggests that …

[HTML][HTML] Dietary iron repletion stimulates hepatic mobilization of vitamin A in previously iron-deficient rats as determined by model-based compartmental analysis

Y Li, CH Wei, MH Green, AC Ross - The Journal of Nutrition, 2020 - Elsevier
Background: Iron deficiency can result in hyporetinolemia and hepatic vitamin A (VA)
sequestration. Objectives: We used model-based compartmental analysis to determine the …