Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …

YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and
tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By …

The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS,
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

Curcumin (diferuloylmethane), a derivative of turmeric is one of the most commonly used
and highly researched phytochemicals. Abundant sources provide interesting insights into …

Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and
S100A9, was originally discovered as immunogenic protein expressed and secreted by …

Since its discovery more than two decades ago the involvement of the Activating protein 1
(AP-1) in proliferation, inflammation, differentiation, apoptosis, cellular migration and wound …

Genetically modified mice have provided important insights into the biological functions of
the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …