In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
C Stonesifer, S Corey, S Ghanekar, Z Diamandis… - Progress in …, 2017 - Elsevier
Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke …
S Feno, G Butera, D Vecellio Reane… - Oxidative medicine …, 2019 - Wiley Online Library
Calcium ions are highly versatile intracellular signals that regulate many cellular processes. The key to achieving this pleiotropic role is the spatiotemporal control of calcium …
K Belarbi, E Cuvelier, A Destée, B Gressier… - Molecular …, 2017 - Springer
Parkinson's disease (PD) is a progressive movement neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain …
M Skonieczna, T Hejmo… - Oxidative Medicine …, 2017 - Wiley Online Library
NADPH oxidases (NOX) are reactive oxygen species‐(ROS‐) generating enzymes regulating numerous redox‐dependent signaling pathways. NOX are important regulators of …
T Maraldi, C Angeloni, C Prata, S Hrelia - Antioxidants, 2021 - mdpi.com
One of the major sources of reactive oxygen species (ROS) generated within stem cells is the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes …
The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However …
YT Zhao, H Yin, C Hu, J Zeng, S Zhang, S Chen… - Frontiers in …, 2022 - frontiersin.org
Anxiety-and depression-like behavior following chemotherapy treatment occurs in cancer patients with high probability and no specific therapeutics are available for treatment and …