The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen,
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Triple‐negative breast cancer (TNBC) is a subgroup of 15%‐20% of diagnosed breast
cancer patients. It is generally considered to be the most difficult breast cancer subtype to …

Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system.
In this review, the authors summarize the current knowledge about the impact of the Notch …

The Notch signaling plays a key role in cell differentiation, survival, and proliferation through
diverse mechanisms. Notch signaling is also involved in vasculogenesis and angiogenesis …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common monogenic disorder of the cerebral …

Notch signaling is an area of great interest in oncology. RO4929097 is a potent and
selective inhibitor of γ-secretase, producing inhibitory activity of Notch signaling in tumor …

Notch receptors are transmembrane receptors that regulate cell fate decisions. There are
four Notch receptors in mammals. Upon binding to members of the Delta and Jagged family …

Background Understanding the molecular control of cell lineages and fate determination in
complex tissues is key to not only understanding the developmental biology and cellular …